×200. Age-related vascular medial cartilage and mineralization may be encountered in the blood vessels of aging rats (Fig. Dilated submucosal glands in the larynx of the rat. Cholesterol clefts in the rat lung. The typical life span is 2.5 - 3.5 years.. 2.44), often containing keratin, are common in the stomach, particularly in the region of the limiting ridge and antral mucosa.  |  Wistar rats are more active than others like Sprague Dawley rats. However, the majority of these effects were more pronounced or earlier detected in Wistar rats. Outbred Rats - Hsd:Sprague Dawley SD - 002. FIGURE 2.22 Eosinophilic inclusions in the olfactory epithelium of the rat nasal turbinate. Germinal centres and lymphoid follicles can occasionally be present in the bone marrow of normal rats (Frith et al 2000b). FIGURE 2.6 Medial hypertrophy in heart artery. Species: Rat. Coat Color Loci: Tyr c. Color: Albino. FIGURE 2.28 Cholesterol clefts in the rat lung. Set alert. This lesion is common and generally occurs due to the presence of hemorrhage in the organs draining into the lymph nodes. Eosinophilic inclusions in the olfactory epithelium of the rat nasal turbinate. ×100. Mineralization of mucus within the lumen of the nasal turbinates of the rat. Squamous cysts (Fig. ×100. Mineralization may occasionally be seen in the walls of the blood vessels of the spleen as well as in the capsule of aging rats (Frith et al 2000b). These lesions may mask or confuse research findings, particularly in inhalation studies. FIGURE 2.30 Pleural lung tag on surface of rat lung. The inclusions are thought to be proteinaceous and the lesion may also be induced by irritant compounds (. Data of all experimental groups were gathered and analyzed by SPSS software (20.0 version) using 2-tailed Pearson's correlation test. ×200. Generally the subcapsular and medullary sinuses are dilated. Reproduction of the rat, mouse, dog, non-human primate and minipig, Non-human primates: Cynomolgus (Macaca fascicularis) and rhesus (Macaca mulatta) macaques and the common marmoset (Callithrix jacchus), Background Lesions in Laboratory Animals A Color Atlas. Isolated cystic spaces in lung parenchyma are rarely seen in rats and are of uncertain origin. For the study of these pathologies, a number of animal models have been developed. ×200. FIGURE 2.7a Vaso vasorum in adventitia of a mesenteric artery blood vessel in the rat. Mineralization (corpora amylacea) of the olfactory epithelium of the rat nasal turbinate. Ilić I, Oršolić N, Rođak E, Odeh D, Lovrić M, Mujkić R, Delaš Aždajić M, Grgić A, Tolušić Levak M, Vargek M, Dmitrović B, Belovari T. PLoS One. 2.6). Some macrophages contain brown pigment which may be hemosiderin (Renne et al 2003) or lipofuscin (Fig. Thymus hemorrhage and eosinophlilic crystals. 2.21). Age-related vascular medial cartilage and mineralization in the tongue of a rat. 2.8) (particularly the medullary or subscapular sinuses) of the lymph nodes are observed commonly in rats. In rats, there are, at present, only four reports of intraoral ‘ectopic’ sebaceous glands in the literature (Bernick & Bavetta 1962, Squamous cysts (Fig. Eosinophilic crystals are occasionally observed free within the alveoli (Renne et al 2003) of rat lungs. FIGURE 2.31 Mineralization of tracheal cartilage in the rat. Mesenchymal proliferation in the subendocardium (Fig. The publicly available database for spontaneous tumors in control Wistar rats is substantially smaller than for either Sprague–Dawley rats or F344 rats; however, it does appear that the total incidence of spontaneous tumors in aged control animals in various Wistar strains is lower than has been reported for Sprague–Dawley and Sprague–Dawley-derived rats [6,43]. Pulp stones often form around cellular debris (Bertram et al 1996). These thrombi may be emboli originating from atrial thromboses in older rats. FIGURE 2.42 Dental dysplasia visible in the rat oral cavity. ×100. Thymic cysts lined by squamous epithelium. A substantial quantity of data on Sprague-Dawley (SD) and Hannover Wistar rats strains have been published concerning their source, diet, and housing conditions, as well as the incidences of nonneoplastic lesions and neoplasms observed in different laboratories. FIGURE 2.34 A hair embolus within an artery in the rat lung, surrounded by inflammatory cells. 2.36b). Later, fibrosis is prominent in aging rats and is generally present in the left ventricle, intraventricular septum and papillary muscle. The gut microbiota composition of the animals of each group was evaluated at the end of the study by real-time PCR. 2.43) (Monticello et al 1990). Multifocal aggregates of alveolar macrophages (Fig. The pathology of the aged rat becomes important in the latter stages of carcinogenicity studies (Chandra & Frith 1992). 2. ×200. ×200. ×100. FIGURE 2.39 Mineralization of mucus within a bronchiole in the rat lung. Background lesions in rats are made up of degenerative, inflammatory, proliferative and congenital changes. Hair shaft emboli or skin fragment emboli are seen in the lungs of animals on intravenous injection studies. FIGURE 2.3 Endocardial mesenchymal proliferation in the rat heart. 2.44), often containing keratin, are common in the stomach, particularly in the region of the limiting ridge and antral mucosa. ×200. 2.24). A strain, according to Webster's, is a group of individuals which share a presumed common ancestry and have clear-cut physiological but not usually morphological distinctions (e.g. The results indicated that wild rats and Long-Evans rats did not differ on any measure, with Fischer-Norway rats being only slightly inferior. However, a direct comparison between Wistar and Sprague-Dawley (SD) Rat as models of high-fat (HF) diet-induced obesity has not been adequately evaluated so far. Pigmented macrophages in the sinuses (Fig. Evid Based Complement Alternat Med. Generally the subcapsular and medullary sinuses are dilated. The Sprague Dawley® outbred model was developed by Sprague Dawley, Inc. NIH received stock from Sprague Dawley, Inc in 1945. 2020 Dec 24;2020:6180310. doi: 10.1155/2020/6180310. ×100. Larger impairments were found in Wistar > Fischer 344 > Dark-Agouti > Sprague-Dawley strains. 2.5). The etiology of this finding is unknown. Eosinophilic inclusions may occur in association with the loss of sensory cells (Renne et al 2009). Morphologically the lesion resembles chemoreceptors such as carotid bodies (Haworth et al 2007). This site needs JavaScript to work properly. This strain was selected by DONALDSON in 1906 at the Wistar Institute (USA), from a batch belonging to Chicago University (RUSSEL-LINDSAY, 1979).The WISTAR rat is an outbred stock, used in all fields of medical and biological research.Its longevity and high rate of spontaneous tumours make it an ideal choice for ageing studies Minimal extramedullary hemopoiesis in a rat spleen. Medial degeneration is common in the coronary arteries of rats and the affected vessels display enlarged, irregularly arranged and sparse nuclei present in a PAS-positive matrix (Ruben 2000). 2.18) or epithelial remnants are observed as a background change in the rat thymus. Recent studies indicate new and improved therapies. FIGURE 2.5 Heart valve cyst in the rat. 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